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Indonesia

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Others

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Sweden

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Turkey

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Uzbekistan

Vietnam

Yemen

<div>
Under this partnership, EVA Pharma to import, market, promote and distribute BeiGene’s flagship Oncology medicines BRUKINSA and TEVIMBRA in Egypt.&nbsp; &nbsp;
DUBAI, CAIRO, Egypt - 27th March 2025 – <a href="https://evapharma.com/" target="_blank" rel="noopener">EVA Pharma</a>,&nbsp; one of the fastest-growing healthcare organizations in the Middle East and Africa, and BeiGene International GmbH (an affiliate of <a href="https://beigene.com/" target="_blank" rel="noopener">BeiGene</a> Ltd., NASDAQ: ONC; HKEX: 06160; SSE: 688235), a global oncology company that intends to change its name to BeOne Medicines Ltd, have announced a strategic partnership to expand treatment options for cancer patients in Egypt. &nbsp; &nbsp;
Under the terms of the agreement, EVA Pharma will begin by launching BRUKINSA (zanubrutinib), a second-generation Bruton Tyrosine Kinase (BTK) inhibitor. Another medicine to be introduced under this partnership is TEVIMBRA (tislelizumab), an immunotherapy that targets the PD-1 pathway. According to the U.S. Food and Drug Administration (FDA), BRUKINSA is approved for the treatment of certain blood cancers, while TEVIMBRA is approved for the treatment of solid tumors.,1,2&nbsp;
&nbsp;
“At BeiGene, our mission is to expand access to innovative oncology treatments for patients worldwide. This partnership with EVA Pharma is a significant step toward achieving that goal in Egypt.&nbsp;
&nbsp;
By combining BeiGene’s advanced therapies, such as BRUKINSA and TEVIMBRA, with EVA Pharma’s strong regional expertise, we are forming a powerful alliance to meet the urgent needs of cancer patients. Together, we are not only delivering hope but also working to raise the standard of cancer care in Egypt and across the region,” said Mohammed Al Kapany, General Manager of BeiGene’s Middle East and Africa (MENA) region.&nbsp;
&nbsp;
“We are eager to provide cancer patients with innovative and accessible therapies. That’s why we are partnering with BeiGene — to improve patient outcomes by increasing access to critical treatments. It is also worth noting that this marks the third global pharmaceutical company to choose EVA Pharma as a partner of choice, a reflection of the trust and credibility we have built over the years,” said Dr. Amgad Talaat, Strategic Alliances Director and Saudi Arabia Cluster Head, EVA Pharma.&nbsp;
&nbsp;
<a href="https://gco.iarc.who.int/media/globocan/factsheets/populations/818-egypt-fact-sheet.pdf" target="_blank" rel="noopener">The Global Cancer Observatory (GLOBOCAN 2022) reports over 366,000 cancer cases in Egypt, with nearly 95,300 cancer-related deaths.</a>3 This partnership was established to address the significant unmet need for advanced oncology treatments in Egypt, reflecting the shared commitment of EVA Pharma and BeiGene to expand access to innovative cancer care.&nbsp;
&nbsp;
It also represents a major milestone in improving access to these innovative therapies across the region.&nbsp;
&nbsp;
Under the agreement, EVA Pharma will lead the importation, marketing, and medical promotion of BeiGene’s oncology therapies in Egypt — treatments that have shown meaningful progress in advancing cancer care. By leveraging EVA Pharma’s deep expertise in distribution, medical affairs,&nbsp;&nbsp;
and regional market dynamics, this collaboration aims to make these innovative options more accessible to patients in Egypt.&nbsp;
&nbsp;
EVA Pharma and BeiGene are also committed to supporting healthcare professionals through ongoing medical education and resources to help optimize patient outcomes. This partnership represents a significant step toward strengthening cancer care in Egypt and contributing to broader efforts to reduce the global cancer burden — delivering renewed hope to patients and their families.&nbsp;
&nbsp;
About TEVIMBRA®(tislelizumab)&nbsp;
&nbsp;
TEVIMBRA is a uniquely designed humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is designed to minimize binding to Fc-gamma (Fcγ) receptors on macrophages, helping the body’s immune cells detect and fight tumors.&nbsp;
TEVIMBRA is the foundational asset of BeiGene’s solid tumor portfolio and has shown potential across multiple tumor types and disease settings. The global TEVIMBRA clinical development program includes almost 14,000 patients enrolled to date in 34 counties and regions across 66 trials, including 20 registration-enabling studies. TEVIMBRA is approved in more than 42 countries, and more than 1.3 million patients have been treated globally.&nbsp;
&nbsp;
About BRUKINSA®(zanubrutinib)&nbsp;
&nbsp;
BRUKINSA is an orally available, small molecule inhibitor of Bruton’s tyrosine kinase (BTK) designed to deliver complete and sustained inhibition of the BTK protein by optimizing bioavailability, half-life, and selectivity. With differentiated pharmacokinetics compared with other approved BTK inhibitors, BRUKINSA has been demonstrated to inhibit the proliferation of malignant B cells within a number of disease-relevant tissues. &nbsp;
 &nbsp;
BRUKINSA has the broadest label globally of any BTK inhibitor and is the only BTK inhibitor to provide the flexibility of once or twice daily dosing. The global BRUKINSA clinical development program includes about 6,000 patients enrolled in 30 countries and regions across more than 35 trials. BRUKINSA is approved in more than 70 markets, and more than 100,000 patients have been treated globally. &nbsp;
&nbsp;
About EVA Pharma&nbsp;
&nbsp;
EVA Pharma is dedicated to improving access to affordable, high-quality medicines around the world, focusing on three core pillars: innovation, development and sustainable access. The company leverages cutting-edge technology at two research centers bringing first-of-its-kind&nbsp;&nbsp;
&nbsp;
capabilities to the Middle East and Africa including mRNA research and development from AI prediction to biologic products.&nbsp;
&nbsp;
With a 5,000-strong team of professionals, EVA Pharma produces more than one million healthcare products a day at four state-of-the-art manufacturing facilities, which are internationally recognized for innovation, and have been approved by multiple regulatory agencies.&nbsp;
&nbsp;
Guided by a relentless drive to ensure sustainable access to pressing, yet unmet, disease areas, the company’s product portfolio focuses on twelve therapeutic areas: Anti-infectives, metabolic health, bone, neuroscience, oncology, respiratory, gynecology, urology and andrology, pediatrics, ophthalmology, gastrointestinal tract, family medicine to meet both local and international demand.&nbsp;
&nbsp;
EVA Pharma is one of the fastest-growing healthcare companies in the Middle East and Africa, with an extensive pan-African presence, while operating in more than 70 countries worldwide.&nbsp;
&nbsp;
For more information, please visit: <a href="http://www.evapharma.com/" target="_blank" rel="noopener">www.evapharma.com</a> &amp; <a href="https://www.evapharma.com/newsroom" target="_blank" rel="noopener">https://www.evapharma.com/newsroom</a> or follow us on <a href="https://www.facebook.com/Evapharma/" target="_blank" rel="noopener">Facebook</a>, <a href="https://www.linkedin.com/company/eva-pharma/" target="_blank" rel="noopener">LinkedIn</a> &amp; <a href="https://www.instagram.com/eva.pharma/" target="_blank" rel="noopener">Instagram</a>  &nbsp;
&nbsp;
About BeiGene&nbsp;
&nbsp;
BeiGene, which plans to change its name to BeOne Medicines Ltd., is a global oncology company that is discovering and developing innovative treatments that are more affordable and accessible to cancer patients worldwide. With a broad portfolio, we are expediting development of our diverse pipeline of novel therapeutics through our internal capabilities and collaborations. We are committed to radically improving access to medicines for far more patients who need them. Our growing global team of nearly 11,000 colleagues spans five continents. To learn more about BeiGene, please visit <a href="https://www.beigene.com/" target="_blank" rel="noopener">www.beigene.com</a> and follow us on <a href="https://www.linkedin.com/search/results/all/?fetchDeterministicClustersOnly=true&amp;heroEntityKey=urn%3Ali%3Aorganization%3A106535894&amp;keywords=beone%20medicines&amp;origin=RICH_QUERY_TYPEAHEAD_HISTORY&amp;position=0&amp;searchId=6405c2b3-1782-41dd-8a8b-fb8b6dde8a40&amp;sid=-Nh&amp;spellCorrectionEnabled=true" target="_blank" rel="noopener">LinkedIn</a>.&nbsp;
&nbsp;
Forward-Looking Statements&nbsp; &nbsp;
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding BeiGene’s ability to deliver transformative therapies to patients with cancer; the potential of&nbsp;&nbsp;
BRUKINSA® (zanubrutinib) and TEVIMBRA® (tislelizumab) to address critical needs in oncology; the future development, regulatory approvals, and commercial success of BRUKINSA and TEVIMBRA; and BeiGene’s plans, commitments, aspirations, and goals under the heading “About BeiGene.”&nbsp;
Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeiGene’s ability to demonstrate the efficacy and safety of its medicines; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing, and progress of clinical trials and marketing approvals; BeiGene’s ability to achieve commercial success for its approved medicines and investigational drug candidates; its ability to obtain and maintain protection of intellectual property; its reliance on third parties to conduct development, manufacturing, commercialization, and other services; its limited experience in&nbsp;&nbsp;
&nbsp;
&nbsp;
obtaining regulatory approvals and commercializing pharmaceutical products; and its ability to obtain additional funding and achieve and maintain profitability.&nbsp;
&nbsp;
Additional information is available in BeiGene’s most recent quarterly report on Form 10-Q, as well as subsequent filings with the U.S. Securities and Exchange Commission. All information in this press release is as of the date hereof, and BeiGene undertakes no duty to update such information unless required by law.&nbsp;
&nbsp;
Issued by:&nbsp;
EVA Pharma, El Sharekat St., El Opera-Abdeen – Cairo - Egypt&nbsp; &nbsp; BeiGene International GmbH, Dubai Science Park, Al Barsha - Al Barsha South - Dubai - United Arab Emirates.&nbsp;
Date of Preparation:&nbsp;
26 March 2025&nbsp;
***************************************************************************************&nbsp;
References&nbsp;
<ol style="margin-top: 0in;" start="1" type="1">
<li class="MsoNormal">BRUKINSA® (zanubrutinib) - U.S. Food and Drug Administration. FDA Approves Zanubrutinib for Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. January 19, 2023. Available at: <a href="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zanubrutinib-chronic-lymphocytic-leukemia-or-small-lymphocytic-lymphoma" target="_blank" rel="noopener">https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-zanubrutinib-chronic-lymphocytic-leukemia-or-small-lymphocytic-lymphoma</a>&nbsp;</li>
</ol>
<ol style="margin-top: 0in;" start="2" type="1">
<li class="MsoNormal">TEVIMBRA® (tislelizumab) - U.S. Food and Drug Administration. Drug Trials Snapshots: TEVIMBRA. March 14, 2024. Available at: <a href="https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-tevimbra" target="_blank" rel="noopener">https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-tevimbra</a>&nbsp;</li>
</ol>
<ol style="margin-top: 0in;" start="3" type="1">
<li class="MsoNormal">International Agency for Research on Cancer. GLOBOCAN 2020: Egypt Fact Sheet. World Health Organization; 2021. Available at: <a href="https://gco.iarc.who.int/media/globocan/factsheets/populations/818-egypt-fact-sheet.pdf" target="_blank" rel="noopener">https://gco.iarc.who.int/media/globocan/factsheets/populations/818-egypt-fact-sheet.pdf</a>.&nbsp; Accessed 21 March 2025.&nbsp;</li>
</ol>
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END&nbsp;
&nbsp;
For media inquiries contact - BeiGene:&nbsp;&nbsp;
&nbsp;
Louise Carter Rosa Soto&nbsp;
Email: <a href="mailto:louise.carter@beigene.com" target="_blank" rel="noopener">louise.carter@beigene.com</a> Email: <a href="mailto:louise.carter@beigene.com" target="_blank" rel="noopener">rosa.soto@beigene.com</a>&nbsp;
&nbsp;
For media inquiries contact – EVA Pharma:&nbsp;&nbsp;
&nbsp;
Ahmed Ellewa&nbsp;
Email: <a href="mailto:ahmed.ellewa@evapharma.com" target="_blank" rel="noopener">ahmed.ellewa@evapharma.com</a>&nbsp;
&nbsp;
&nbsp;
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Press Release

EVA Pharma and BeiGene Announce a Strategic Partnership to Bring Innovative Oncology Therapies to Patients in Egypt

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Lilly and EVA Pharma announce regulatory approval and release of locally manufactured insulin in Egypt

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Under this royalty-free voluntary licensing agreement EVA Pharma will manufacture and supply Lenacapavir active pharmaceutical ingredient and finished pharmaceutical product.
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CAIRO, October 3, 2024&nbsp;–<a href="https://c212.net/c/link/?t=0&amp;l=en&amp;o=3735678-1&amp;h=1130473503&amp;u=http%3A%2F%2Fwww.evapharma.com%2F&amp;a=EVA+Pharma" target="_blank" rel="noopener"><span style="font-size: 11.0pt; font-family: 'IBM Plex Sans Arabic',sans-serif; mso-fareast-font-family: 'Times New Roman'; color: #007bff; border: none windowtext 1.0pt; mso-border-alt: none windowtext 0in; padding: 0in;">EVA Pharma</a>&nbsp;announced today a non-exclusive, royalty-free voluntary licensing agreement signed with <a href="https://www.gilead.com/news/news-details/2024/gilead-signs-royalty-free-voluntary-licensing-agreements-with-six-generic-manufacturers-to-increase-access-to-lenacapavir-for-hiv-prevention-in-high-incidence-resource-limited-countries">Gilead</a>, allowing EVA Pharma to manufacture and supply generic lenacapavir in form of active pharmaceutical ingredient and finished pharmaceutical product. This agreement includes the technology transfer of know-how to make and use lenacapavir allowing for sustainable accessibility to lenacapavir in 120 high-incidence, resource-limited countries through EVA Pharma’s local manufacturing capabilities and strong foothold in Africa.
&nbsp;
The agreement covers lenacapavir for HIV treatment in heavily treatment-experienced (HTE) adults with multi-drug-resistant HIV, as well as lenacapavir for HIV prevention (pending approval). Gilead is exploring frameworks such as the European Medicines Agency’s EU Medicines for All with the aim of expediting both U.S. FDA procedures and the attainment of WHO prequalification. This will enable EVA Pharma to submit its high-quality generic lenacapavir for multiple regulatory authorities to support demand and broaden accessibility across 120 countries.
&nbsp;
“<a href="https://www.unaids.org/sites/default/files/media_asset/2024-unaids-global-aids-update_en.pdf">The urgency of NOW</a> demands that we go fast and far to end HIV/AIDS. This goal is only reached through collective efforts, from innovation to sustainable access to medicines.” said Riad Armanious, CEO of EVA Pharma. “To this commitment we stand our ground as the sole licensee on Africa, EVA Pharma has already rolled the ball on fast-track actions towards our joint mission with Gilead. Combining Gilead’s expertise and EVA Pharma’s capabilities and reach we ensure that no one is left behind in the fight against HIV.”
&nbsp;
&nbsp;
&nbsp;
“EVA Pharma has been committed to the fight against HIV since 2003, consistently empowering governments and healthcare systems to support patient care across Africa” said Amgad Talaat, Strategic Alliances Director at EVA Pharma. “In our ongoing effort to ensure sustainable access, EVA Pharma has expanded its focus to localizing drug substance production. In collaboration with Gilead we have been setting numerous firsts in the area of generic voluntary licensing, from combatting HCV to making remdesivir available for COVID patients. And now, we embark on another significant milestone by supplying lenacapavir to patients across the continent, including South Africa for the first time” 
&nbsp;
Of the six generic manufacturers in Gilead’s voluntary licensing agreement, EVA Pharma is the sole local manufacturer in Africa. Responding to the urgency of this shared mission, EVA Pharma expects to complete lenacapavir API manufacturing by the end of 2024, following the completion of the tech-transfer from Gilead, paving the way for the production of lenacapavir finished product. The company expects to begin supplying the high-quality, African-made lenacapavir within 25 months. Leveraging its extensive pan-African reach, EVA Pharma will supply the medicine to 120 countries, with the first phase of export including 18 countries representing the highest incidence rate (about 70% of the HIV burden in the countries named in the license) to receive lenacapavir as quickly as possible. These countries are Botswana, Eswatini, Ethiopia, Kenya, Lesotho, Malawi, Mozambique, Namibia, Nigeria, Philippines, Rwanda, South Africa, Tanzania, Thailand, Uganda, Vietnam, Zambia and Zimbabwe. 
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&nbsp;
--end of release--
&nbsp;
&nbsp;
About EVA Pharma
EVA Pharma is dedicated to improving access to affordable, high-quality medicines around the world, focusing on three core pillars: innovation, development and sustainable access. The company leverages cutting-edge technology at two research centers bringing first-of-its-kind capabilities to the Middle East and Africa including mRNA research and development from AI prediction to biologic product.
&nbsp;
With a 5,000-strong team of professionals, EVA Pharma produces more than one million healthcare products a day at four state-of-the-art manufacturing facilities, which are internationally recognized for innovation, and have been approved by multiple regulatory agencies.
&nbsp;
Guided by a relentless drive to ensure sustainable access to pressing, yet unmet, disease areas, the company’s product portfolio focuses on twelve therapeutic areas: Anti-infectives, metabolic health, bone, neuroscience, oncology, respiratory, gynecology, urology and andrology, pediatrics, ophthalmology, gastrointestinal tract, family medicine to meet both local and international demand.
&nbsp;
EVA Pharma is one of the fastest-growing healthcare companies in the Middle East and Africa, with an extensive pan-African presence, while operating in more than 70 countries worldwide.
For more information, please visit: <a href="http://www.evapharma.com/">www.evapharma.com</a> &amp; <a href="https://www.evapharma.com/newsroom">https://www.evapharma.com/newsroom</a> or follow us on <a href="https://www.facebook.com/Evapharma/" target="_blank" rel="noopener">Facebook</a>, <a href="https://www.linkedin.com/company/eva-pharma/" target="_blank" rel="noopener">LinkedIn</a> &amp; <a href="https://www.instagram.com/eva.pharma/" target="_blank" rel="noopener">Instagram</a> &nbsp;
&nbsp;
&nbsp;
About Gilead Sciences:
Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.
&nbsp;
&nbsp;
About Lenacapavir
Lenacapavir is approved in multiple countries for the treatment of adults with multi-drug-resistant HIV in combination with other antiretrovirals. The use of lenacapavir for HIV prevention is investigational and the safety and efficacy of lenacapavir for this use have not been established.
The multi-stage mechanism of action of lenacapavir is distinguishable from other currently approved classes of antiviral agents. While most antivirals act on just one stage of viral replication, lenacapavir is designed to inhibit HIV at multiple stages of its lifecycle and has no known cross resistance exhibited in vitro to other existing drug classes.
Lenacapavir is being evaluated as a long-acting option in multiple ongoing and planned early and late-stage clinical studies in Gilead's HIV prevention and treatment research program. Lenacapavir is being developed as a foundation for potential future HIV therapies with the goal of offering both long-acting oral and injectable options with several dosing frequencies, in combination or as a mono agent, that help address individual needs and preferences of people and communities affected by HIV.

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EVA Pharma Signs a Voluntary Licensing Agreement with Gilead to Increase Access to Lenacapavir in 120 Countries with High HIV Incidence and Limited Resources

Highlights

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Licensing from EVA Pharma

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CPHI Worldwide

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We believe in the catalytic power of collaboration. Because better health should not depend on geography, we are committed to building global partnerships that translate science into impact and deliver meaningful outcomes for patients worldwide.

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Collaborating for Global Health&nbsp;

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Our Current Collaborations in Action

We bridge the globe as one of the fastest-growing healthcare companies in the MENA region, with an extensive pan-African presence while delivering high-quality healthcare solutions to more than 60 countries worldwide.

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Our Global Presence

We focus on highly differentiated and innovative products to complement our portfolio, we are open to different business models including licensing of FDF and/or Bulk with supply, in addition to Tech transfer&nbsp; Our areas of focus are: Biosimilars, mRNA technology, small molecules with focus on oncology and hormones, and Vaccines with focus on epidemic diseases, Flu and COVID-19.&nbsp;&nbsp;

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In-Licensing

Our Europe Product Portfolio contains 35+ products in EU CTD format, covering a wide range of differentiated dosage forms, including DPIs, transdermal patches, solid oral dosage forms, injectables, and ophthalmic preparations. Our portfolio spans multiple therapeutic areas, including Antiemetics, Anti-infectives, Cardiovascular, Diabetes, Neurology, Ophthalmology, Pain Management, Respiratory, Rheumatology, Urology, and Andrology.

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Out-Licensing

Discover our Contract Manufacturing Services

We are your Contract Manufacturing partner, driven by one clear purpose: expanding patient access to high-quality medicines. With a reliable, agile, and cost-effective platform, we bridge unmet medical needs while ensuring every product is delivered with excellence, compliance, and care.&nbsp;&nbsp;
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Contract Manufacturing

EVA Pharma and Lilly's partnership has led to significant milestones to begin distribution of the African-made insulin products and to reach one million people per year by 2030. This collaboration is part of the Lilly 30x30 initiative, which aims to improve access to quality healthcare for 30 million people living in limited -resource settings, annually, by 2030. Another achieved milestone in this collaboration is the launch of Verzenio in Egypt as part of the "100 Million Health" initiative, aiming to treat over 20,000 breast cancer patients annually. These achievements underscore the effectiveness of their collaboration in expanding healthcare access and delivering essential treatments across key regions.

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EVA Pharma, in strategic alliance with Gilead, has achieved remarkable public health milestones, notably in Egypt and India. Together, they have played a pivotal role in reducing the HCV disease rate in Egypt to less than 1%, a significant public health victory. Additionally, their collaboration facilitated the distribution of Remdesivir to 127 countries, with over 1,010,746 vials provided in Egypt and 300,150 in India, crucial in the fight against COVID-19. Moreover, their efforts have reached over 8 millions people in Egypt, breaking the stigma surrounding HIV and fostering a more informed and compassionate society. These successes underscore the power of strategic partnerships in addressing global health challenges.

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On 27th March 2025, EVA Pharma, and BeiGene International GmbH (BeOne Medicines Ltd) have announced a strategic partnership to expand treatment options for cancer patients in Egypt. Under the terms of the agreement, EVA Pharma will begin by launching BRUKINSA (zanubrutinib), a second-generation Bruton Tyrosine Kinase (BTK) inhibitor. Another medicine to be introduced under this partnership is TEVIMBRA (tislelizumab), an immunotherapy that targets the PD-1 pathway.

Collaborating for Global Health

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Contract Manufacturing

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