For diabetic polyneuropathy
Thiotacid tablets: Each tablet contains:
|Thioctic acid (lipoic acid)
Thiotacid 600 mg tablets: Each tablet contains:
|Thioctic acid (lipoic acid)||600 mg
Thioctic acid is a biologically occurring substance which acts as a cofactor in the pyruvate - dehydrogenase complex, the alpha ketoglutarate-dehydrogenase complex, and the amino acid hydrogenase complex. Reduced levels of thioctic acid have been found in patients with liver cirrhosis, diabetes mellitus, atherosclerosis, and polyneuritis.
During the metabolic process thioctic acid may be transformed from its oxidized form (with the disulfide bridge in the molecule) to its reduced dihydroform with two free sulfide groups. Both forms have strong antitoxin effects. They protect the cell from free radicals that result from intermediate metabolites or from the degradation of exogenous molecules and from heavy metals.
Dihydrolipoic acid also scavenges superoxide radicals and hydroxyl radicals and prevents lipid peroxidation. Thioctic acid delays the onset of motor hexacarbon-induced neuropathy, and dihydrolipoate protects neurons against ischemic damage by inhibiting accumulation of free oxygen radicals in cerebral tissues.
Hypersensitivity to thioctic acid.
Dose must be adjusted in diabetic patients as thioctic acid may decrease blood sugar levels of glucose & has an additive effect to insulin and other hypoglycemic medications.
Animal studies have not demonstrated teratogenic effects, there are no adequate studies in humans, and therefore thioctic acid should only be used if the benefits to the mother outweigh the potential risks to the fetus.
|Box of 2 strips, each of 10 tablets||300 mg
|Box of 2 strips, each of 10 tablets