Each tablet contains:
|Memantine HCl||10 mg|
Pharmacological Actions. There is increasing evidence that malfunctioning of glutamatergic neurotransmission, in particular at NMDA- receptors, contributes to both expression of symptoms and disease progression in neurodegenerative dementia. Memantine is a voltage-dependent, moderate-affinity uncompetitive NMDA -receptor antagonist. It modulates the effects of pathologically elevated tonic levels of glutamate that may lead to neuronal dysfunction.
Memantine is contraindicated in patients with Known hypersensitivity to memantine hydrochloride or to any of the product excipients.
|Nervous system disorders:
|Infections and infestations:||Fungal Infections|
Due to the pharmacological effects and the mechanism of action of memantine, the following interactions may occur:
The mode of action suggests that the effects of L-dopa, dopaminergic agonists, and anticholinergics may be enhanced by concomitant treatment with NMDA -antagonists such as memantine. The effects of barbiturates and neuroleptics may be reduced. Concomitant administration of memantine with the antispasmodic agent, dantrolene or baclofen, can modify their effects and a dosage adjustment may be necessary.
Concomitant use of memantine and amantadine should be avoided, owing to the risk of pharmacotoxic psychosis. Other drugs such as cimetidine, ranitidine, procainamide, quinidine, quinine and nicotine that use the same renal cationic transport system as amantadine may also possibly interact with memantine leading to a potential risk of increased plasma levels.
There may be a possibility of reduced serum level of hydrochlorothiazide (HCT) when memantine is co-administered with HCT or any combination with HCT.
In post marketing experience isolated cases with INR increases have been reported in patients concomitantly treated with warfarin , although no relationship has been established, close monitoring of prothrombin time or INR is advisable for patients concomitantly treated with oral anticoagulants.
Pregnancy and Lactation:
No clinical data on exposed pregnancies are available. Memantine should not be used during pregnancy unless clearly necessary.
It is not known whether memantine is excreted in human breast milk. Memantine administration to nursing women should be avoided if clinically possible.
Keep in a cool dry place away from light, below 30 °C.
Pack of one or two blisters AL/PVC each of 10 tablets.