Each scored film coated tablet contains
Paroxetine (as hydrochloride hemihydrate)
Paroxetine hydrochloride is the salt of a phenylpiperidine compound, it is an oral psychotropic agent with a chemical structure that is unrelated to other selective serotonin inhibitors. Its antidepressant action is thought to be related to its potent and selective inhibition of serotonin (5- hydroxytryptamine, 5-HT) reuptake in brain neurons.
Commonly observed adverse effects associated with the use of Paroxetine are mainly: asthenia, sweating, nausea, decreased appetite, somnolence, dizziness, tremor, nervousness and ejaculatory changes (in clinical trials Paroxetine 20 mg/day exerted a strong delay in intravaginal latency time).
Paroxetine is usually administered in the morning as a single daily dose with or without food according to the following recommended regimen:
Paroxetine should be used with caution when administered with drugs that may affect the seretonergic neurotransmitter systems, tricyclic antidepressants, phenobarbital, phenytoin, lithium, digoxin, theophylline, fosaprenavir, ritonavir, triptans, cimetidine, drugs affecting hepatic metabolism, drugs metabolized by CYP2D6 and cytochrome CYP344, those highly bound to plasma protein and concomitant use of alcohol.
Boxes of two blisters each contain 10 tablets.