Conventin Cap

Gabapentin is an anti-epileptic drug of a new generation that increases the gamma-aminobutyric acid (GABA) levels, it is structurally related to the neurotransmitter GABA, by the addition of a cyclohexyl group to its backbone, but does not interact with GABAA or GABAB receptors of GABA uptake carriers of brain.
Gabapentin interacts with a high affinity-binding site in brain membranes, which is an auxiliary subunit of voltage-sensitive calcium ion channels. Gabapentin is not appreciably metabolized in the body and most of the dose is excreted unchanged in the urine. Peak plasma concentrations are usually achieved within 3 hours and elimination half-life is about 5 to 7 hours.

• For the treatment of neuropathic pain in diabetic polyneuropathy and post-herpeticneuralgia.
• In treatment of partial seizures with or without secondary generalization.
• As an adjunctive in patients unresponsive to or intolerant to standard anti-epileptics.

In known hypersensitivity to any of the ingredients.

The most frequently reported adverse reactions are somnolence, backache, dizziness, fatigue, headache, nausea and vomiting.

The following instructions apply unless otherwise prescribed by the physician:

• 100 mg three times on day 1, then 200 mg three times on day 2, then 300mg three times on day 3.
• The dose is increased on day 4 to be 400mg three times daily and increased gradually to reach 2400mg daily by week three with a maximum safety daily dose of 3600mg Gabapentin, regarding that the total daily dose should be divided into three single doses in each case.
• The first dose is to be administered before sleep to avoid any side effect.
• In patients with impaired renal failure or those undergoing haemodialysis, dosage adjustment is necessary according to physician\\\'s instructions.
• Caution is required during termination of Conventin therapy with a gradual withdrawal by reduction of the dose over at least 7 days.

Conventin capsule should be administered two hours after the intake of antacids.

• Patients should be advised not to drive or operate any machinery while under Conventin therapy.
• Should be used with caution in patients with mixed seizure syndrome that include absence syndrome.
• Should be used in pregnancy and during lactation only if the benefits clearly outweigh the potential risk.
• False positive readings with some urinary protein tests may occur.
• Patients with diabetesmellitus should monitor their blood sugar level and the antidiabetic dose should be adjusted if necessary.

Conventin 100mg: Box of 1 or 2 strips, each of 10 capsules.
Conventin 400mg: Box of 1 or 2 strips, each of 10 capsules.